Interaction of systemic fluconazole with oral direct anticoagulants: is there an increased risk of bleeding?

Interacción de fluconazol sistémico con anticoagulantes directos orales: ¿existe mayor riesgo de sangrado?

Authors

  • Yelson Alejandro Picón-Jaimes Fac Ciències Salut Blanquerna, Univ Ramon Llul. Barcelona, España.
  • Juan Sebastián Soto-Naranjo Departamento de Medicina, Universidad Santiago de Cali. Cali, Colombia.
  • Héctor Fabio Mena-Falla Departamento de Medicina, Universidad Santiago de Cali. Cali, Colombia.
  • Zaira Yamile Rincón-Lozano Departamento de Medicina, Universidad Cooperativa de Colombia. Villavicencio, Colombia.
  • Johana Andrea Estupiñan-Zaldua Departamento de Medicina, Universidad Juan N Corpas. Bogotá, Colombia.

DOI:

https://doi.org/10.22258/hgh.2023.71.144

Abstract

At present, there is no high-level or detailed evidence regarding this type of interaction, which is likely due to genetic and epigenetic differences in the populations where it is studied. There is also limited literature providing a precise description of the cellular or molecular mechanisms associated with these interactions; most of the available evidence is clinical.

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Author Biographies

Yelson Alejandro Picón-Jaimes , Fac Ciències Salut Blanquerna, Univ Ramon Llul. Barcelona, España.

Fac Ciències Salut Blanquerna, Univ Ramon Llul, Barcelona, España. MD, Esp, MSc, PhD(c)

Juan Sebastián Soto-Naranjo, Departamento de Medicina, Universidad Santiago de Cali. Cali, Colombia.

Departamento de Medicina, Universidad Santiago de Cali, Cali, Colombia. MD

Héctor Fabio Mena-Falla, Departamento de Medicina, Universidad Santiago de Cali. Cali, Colombia.

Departamento de Medicina, Universidad Santiago de Cali, Cali, Colombia. MD

Zaira Yamile Rincón-Lozano, Departamento de Medicina, Universidad Cooperativa de Colombia. Villavicencio, Colombia.

Departamento de Medicina, Universidad Cooperativa de Colombia, Villavicencio, Colombia. MD

Johana Andrea Estupiñan-Zaldua, Departamento de Medicina, Universidad Juan N Corpas. Bogotá, Colombia.

Departamento de Medicina, Universidad Juan N Corpas, Bogotá, Colombia. MD

References

Takahashi M, Okawa K, Morimoto T, et al. Impact of direct oral anticoagulant use on mortality in very old patients with non-valvular atrial fibrillation. Age Ageing. 2022; 51(7):afac146. doi: 10.1093/ageing/afac146.

Bassand JP, Virdone S, Badoz M, et al. Bleeding and related mortality with NOACs and VKAs in newly diagnosed atrial fibrillation: results from the GARFIELD-AF registry. Blood Adv. 2021; 5(4):1081-1091. doi: 10.1182/bloodadvances.2020003560.

Cid A, Smetana ME, Hebert C, Coe K, Smith JM. Impact of concomitant fluconazole on direct oral anticoagulant bleeding risk. Pharmacotherapy. 2022; 42(12):880-889. doi: 10.1002/phar.2738

Holt A, Strange JE, Rasmussen PV, et al. Bleeding Risk Following Systemic Fluconazole or Topical Azoles in Patients with Atrial Fibrillation on Apixaban, Rivaroxaban, or Dabigatran. Am J Med. 2022; 135(5):595-602.e5.

Yu DT, Peterson JF, Seger DL, Gerth WC, Bates DW. Frequency of potential azole drug-drug interactions and consequences of potential fluconazole drug interactions. Pharmacoepidemiol Drug Saf. 2005; 14(11):755-67. doi: 10.1002/pds.1073.

Govindarajan A, Bistas KG, Ingold CJ, et al. Fluconazole. [Updated 2022 Jun 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537158/

Lozada-Martinez ID, Suarez-Causado A, Solana-Tinoco JB. Ethnicity, genetic variants, risk factors and cholelithiasis: The need for eco-epidemiological studies and genomic analysis in Latin American surgery. Int J Surg. 2022; 99:106589. Disponible en: doi: 10.1016/j.ijsu.2022.106589.

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Published

2023-06-25

How to Cite

Picón-Jaimes , Y. A. ., Soto-Naranjo, J. S. ., Mena-Falla, H. F. ., Rincón-Lozano, Z. Y. ., & Estupiñan-Zaldua, J. A. . (2023). Interaction of systemic fluconazole with oral direct anticoagulants: is there an increased risk of bleeding? Interacción de fluconazol sistémico con anticoagulantes directos orales: ¿existe mayor riesgo de sangrado?. Peruvian Journal of Health Care and Global Health, 7(1). https://doi.org/10.22258/hgh.2023.71.144

Issue

Vol. 7 No. 1 (2023)

Section

Letters to the editor

License

Copyright (c) 2023 Yelson Alejandro Picón-Jaimes , Juan Sebastián Soto-Naranjo, Héctor Fabio Mena.Falla, Zaira Yamile Rincón-Lozano, Johana Andrea Estupiñan-Zaldua

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