Novas Estratégias de Manejo na Colite Ulcerativa: Uma Revisão Narrativa
New management strategies in ulcerative colitis: a narrative review
DOI:
https://doi.org/10.22258/hgh.2026.101.283Resumo
Introdução: A colite ulcerativa é uma doença inflamatória intestinal crônica, associada a elevada morbidade, que requer inovações terapêuticas para melhorar os desfechos clínicos. Objetivo: Avaliar as novas estratégias terapêuticas para a colite ulcerativa moderada a grave. Métodos: Foi realizada uma revisão narrativa baseada em literatura científica indexada nas bases PubMed, EMBASE e Cochrane, sem restrição de idioma. A busca foi conduzida entre janeiro de 2015 e junho de 2025, utilizando palavras-chave como “inibidores de Janus kinase (JAK)”, “inibidores da fosfodiesterase 4 (PDE4)”, “moduladores do receptor de esfingosina acoplados à proteína G” e “transplante de microbiota fecal”. Resultados: Os fármacos inibidores de JAK (tofacitinibe, upadacitinibe) demonstraram eficácia na indução de remissão clínica precoce, com melhorias significativas nos sintomas e nos marcadores inflamatórios. Os moduladores do receptor de esfingosina (ozanimode) mostraram capacidade de reduzir a inflamação sistêmica e local, com um perfil de segurança favorável. O transplante de microbiota fecal emergiu como uma estratégia com potencial terapêutico, embora com taxas de resposta variáveis. Conclusão: Essas terapias representam avanços significativos no manejo da colite ulcerativa. No entanto, é necessária a padronização dos critérios de seleção de pacientes e dos protocolos terapêuticos, bem como a realização de estudos longitudinais que permitam avaliar sua segurança e eficácia a longo prazo.Downloads
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