Desquamative Perioral Dermatitis in Pregnancy: A Case Report
Dermatitis peribucal descamativa en el embarazo: Reporte de caso
DOI:
https://doi.org/10.22258/hgh.v10i1.397Abstract
Desquamative perioral dermatitis is an inflammatory dermatosis affecting the perioral region. Its onset or exacerbation during pregnancy may be influenced by hormonal changes and the increased skin reactivity characteristic of this stage. The aim of this study is to describe the clinical characteristics, triggering factors, diagnosis, and management of desquamative perioral dermatitis, highlighting safe therapeutic considerations during pregnancy. We present the case of a 32-year-old pregnant patient, in her 11th week of gestation, with a history of intermittent perioral erythema of several years' duration and repeated use of high-potency topical corticosteroids. The diagnosis was established through clinical evaluation, based on the typical morphology and distribution of the lesions, characterized by a desquamative erythematous plaque located in the perioral region, predominantly on the chin and nasolabial folds, sparing the vermilion border of the lips, and accompanied by moderate pruritus, without signs of superinfection. Hormonal changes associated with pregnancy and a history of prolonged use of topical corticosteroids were identified as predisposing and triggering factors. Management consisted of discontinuing the topical corticosteroids and recommending gentle skin care measures, with a favorable clinical outcome. In conclusion, perioral scaly dermatitis can be exacerbated during pregnancy; its diagnosis is primarily clinical, and treatment should focus on eliminating triggering factors and using safe topical therapies, allowing for a favorable outcome without compromising maternal and fetal health. Keywords: Dermatitis, Perioral; Corticosteroids; Erythema; Pregnancy (Source: MeSH, NLM).Downloads
References
Shah B, Goldberg R, Klar T. Perioral dermatitis in older adults. In: Norman R, Dharmarajan TS, editors. Geriatric dermatology. Cham: Springer Nature Switzerland; 2026: 1–11. DOI:10.1007/978-3-031-53888-9_100-1.
Tolaymat L, Syed HA, Hall MR. Perioral dermatitis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. https://www.ncbi.nlm.nih.gov/books/NBK525968/
Meena S, Gupta L, Khare A, Balai M, Mittal A, Mehta S, et al. Topical corticosteroids abuse: A clinical study of cutaneous adverse effects. Indian J Dermatol. 2017;62(6):675. DOI: 10.4103/ijd.IJD_110_17.
Alhomieed MF, Al Hartany LO, Alghorab MA, Alsharif A, Kaleemullah A, Wasaya HI, et al. The effect of pregnancy on dermatological disorders: A systematic review. Clinics and Practice. 2025;15(4):68. DOI:10.3390/clinpract15040068.
Bhatt S, Neema S, Vasudevan B. Perioral pigmentation. Pigment Int. 2022;9(3):151–165. DOI:10.4103/pigmentinternational.pigmentinternational_14_22.
Putra IB, Jusuf NK, Dewi NK. Skin changes and safety profile of topical products during pregnancy. J Clin Aesthet Dermatol. 2022;15(2):49–57.
Mochizuki A, Osaka T, Fukuya Y, Yanagisawa N, Ishiguro N. Comparative analysis of the skin microbiota of rosacea, steroid-induced rosacea and perioral dermatitis. Exp Dermatol. 2025;34(3):e70084. DOI:10.1111/exd.70084.
Acevedo-Fontanez LA, Sánchez-Feliciano A, Ershadi S, Reichenberg J, Eichenfield LF, Barbieri JS. Periorificial dermatitis: Pathophysiology, diagnosis, and management. J Am Acad Dermatol. 2025: S0190-9622(25)03138-X. DOI: 10.1016/j.jaad.2025.10.138.
Searle T, Ali FR, Al-Niaimi F. Perioral dermatitis: Diagnosis, proposed etiologies, and management. J Cosmet Dermatol. 2021;20(12):3839–3848. DOI:10.1111/jocd.14060.
Diehl KL, Cohen PR. Topical steroid-induced perioral dermatitis: Case report of a man who developed topical steroid-induced rosacea-like dermatitis (TOP SIDE RED). Cureus. 2021;13(4):e14443. DOI: 10.7759/cureus.14443.
Gupta SN, Madke B, Ganjre S, Jawade S, Kondalkar A. Cutaneous changes during pregnancy: A comprehensive review. Cureus. 2024;16(9):e69986. DOI:10.7759/cureus.69986.
Lugovic-Mihic L, Spiljak B, Blagec T, Delas Azdajic M, Franceschi N, Gasic A, et al. Factors participating in the occurrence of inflammation of the lips (cheilitis) and perioral skin. Cosmetics. 2023;10(1):9. DOI:10.3390/cosmetics10010009.
Schaller M, Lenders D, Handgretinger G, Gawaz A. Topical ivermectin 10 mg/g cream alone or in combination with oral doxycycline for patients with perioral dermatitis (POD): A retrospective case series. J Dtsch Dermatol Ges. 2025;23(6):759–762. DOI:10.1111/ddg.15691.
Baquedano-Ordoñez A, Gradis-Santos O, Aguilar-Gutiérrez K. Manejo de la dermatitis perioral: reporte de un caso. Rev Hisp Cienc Salud. 2023;8(4):148–152. DOI:10.56239/rhcs.2022.84.580.
Tempark T, Shwayder TA. Perioral dermatitis: A review of the condition with special attention to treatment options. Am J Clin Dermatol. 2014;15(2):101–113. DOI:10.1007/s40257-014-0067-7.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Natacha Belén Andrade-Cabrera, Katty Magdalena Barahona-Ochoa

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- The authors will retain their copyright and will guarantee to the journal right of first publication of their work, which will simultaneously be under a Creative Commons Attribution 4.0 License that allows third parties to share the work whenever attribuying their author and first publication in this journal.
- The Author is able to enter into separate, additional contractual arrangements for the nonexclusive distribution of the journal's published version of the Work (e.g., post it to an institutional repository or publish it in a book), as long as there is provided in the document an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post online a pre-publication manuscript (but not the Publisher’s final formatted PDF version of the Work) in institutional repositories or on their Websites prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (see The Effect of Open Access).






