Frequency of factors associated with cervical premalignant lesions among women treated in Metropolitan Lima
Frecuencia de factores asociados a lesiones premalignas cervicales en mujeres atendidas en Lima Metropolitana
DOI:
https://doi.org/10.22258/hgh.2026.101.282Abstract
Introduction: Cervical cancer is preceded by premalignant lesions such as cervical intraepithelial neoplasia (CIN). Objective: This study aimed to describe the frequency of factors associated with CIN in women treated at a Social Health Insurance (EsSalud) hospital in Metropolitan Lima during 2023 and 2024. Materials and Methods: We conducted a cross-sectional observational study through a review of clinical records at Hospital III Suárez Angamos in Metropolitan Lima. Women with a confirmed diagnosis of CIN (ICD-10 codes N87.9, N87.1, or D06.9) during 2023 and 2024 were included. Results: A total of 341 patients with a confirmed diagnosis of CIN were included: 34.6 percent had CIN I, 47.5 percent CIN II, and 17.9 percent CIN III. Among women with CIN, 69.8 percent were aged forty years or older, 60.1 percent had a higher education level, 89.7 percent reported no tobacco use, 58.9 percent were multiparous, 91.7 percent had five or fewer sexual partners, 63.5 percent did not report early initiation of sexual intercourse, and 72.1 percent had an interval of four years or more between menarche and first sexual intercourse. No statistically significant differences were found in the distribution of the evaluated factors according to lesion grade. Conclusions: Most women were diagnosed with CIN II, and the most frequent associated factors were multiparity and older age. These findings highlight the need to strengthen population-based cervical cancer screening. Key words: Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Risk Factors; Women’s Health, Peru (Source: MeSH, NLM).Downloads
References
International Agency for Research on Cancer . Global Cancer Observatory: Cancer Today - Data visualization: compare populations, . 2024 [citado el 31 de agosto de 2025]. https://gco.iarc.who.int/today/en/dataviz/bars-compare-populations?mode=cancer&types=0_1&cancers=23&populations=604&group_populations=0&sort_by=value1&key=total
Centro Nacional de Epidemiología, Prevención y Control de Enfermedades. Tablero de Consulta de Cáncer. Centro Nacional de Epidemiología, Prevención y Control de Enfermedades - MINSA. 2025 [citado el 31 de agosto de 2025]. https://www.dge.gob.pe/sala-cancer/tablero.html
Loopik DL, Bentley HA, Eijgenraam MN, IntHout J, Bekkers RLM, Bentley JR. The Natural History of Cervical Intraepithelial Neoplasia Grades 1, 2, and 3: A Systematic Review and Meta-analysis. J Low Genit Tract Dis. 2021;25(3):221–31. DOI:10.1097/LGT.0000000000000604.
Abera GB, Yebyo HG, Hailekiros H, Niguse S, Berhe Y, Gigar G, et al. Epidemiology of pre-cancerous cervical lesion and risk factors among adult women in Tigray, Ethiopia. PLoS One. 2023;18(1):e0280191. DOI:10.1371/journal.pone.0280191.
Bekos C, Schwameis R, Heinze G, Gärner M, Grimm C, Joura E, et al. Influence of age on histologic outcome of cervical intraepithelial neoplasia during observational management: results from large cohort, systematic review, meta-analysis. Sci Rep. 2018;8 (1):6383. DOI:10.1038/s41598-018-24882-2.
Li X, Hu SY, He Y, Hernandez Donoso L, Qu KQ, Van Kriekinge G, et al. Systematic literature review of risk factors for cervical cancer in the Chinese population. Womens Health (Lond). 2018;14:1745506518816599. DOI:10.1177/1745506518816599.
Nagelhout G, Ebisch RM, Van Der Hel O, Meerkerk G-J, Magnée T, De Bruijn T, et al. Is smoking an independent risk factor for developing cervical intra-epithelial neoplasia and cervical cancer? A systematic review and meta-analysis. Expert Rev Anticancer Ther. 2021;21(7):781–794. DOI:10.1080/14737140.2021.1888719.
Durán Valverde WO. Lesiones premalignas y malignas del cáncer de cuello uterino en mujeres de Lima Norte 2019. Universidad Nacional Federico Villarreal. 2022 [citado el 29 de marzo de 2024]. https://repositorio.unfv.edu.pe/handle/20.500.13084/6703.
Miñope M. Factores de riesgo relacionados a las lesiones escamosas intraepiteliales del cérvix en mujeres atendidas en el hospital nacional Arzobispo Loayza 2020. Lima: Universidad Privada Norbert Wiener; 2021. https://hdl.handle.net/20.500.13053/5154.
Ephrem Dibisa K, Tamiru Dinka M, Mekonen Moti L, Fetensa G. Precancerous Lesion of the Cervix and Associated Factors Among Women of West Wollega, West Ethiopia, 2022. Cancer Control. 2022;29: 107327482211179. DOI: 10.1177/10732748221117900.
Ruiz ÁM, Ruiz JE, Gavilanes AV, Eriksson T, Lehtinen M, Pérez G, et al. Proximity of First Sexual Intercourse to Menarche and Risk of High-Grade Cervical Disease. The Journal of Infectious Diseases. 2012;206(12):1887–96. DOI: 10.1093/infdis/jis612.
Mullar D da SP, Souza RJ de, Oliveira MAP, Soares LC. Risk prediction for HPV-induced lesions in early sexual intercourse. Research, Society and Development. 2022;11(11):e103111133571–e103111133571. DOI: 10.33448/rsd-v11i11.33571.
Ssedyabane F, Niyonzima N, Nambi Najjuma J, Birungi A, Atwine R, Tusubira D, et al. Prevalence of cervical intraepithelial lesions and associated factors among women attending a cervical cancer clinic in Western Uganda; results based on Pap smear cytology. SAGE Open Med. 2024;12:20503121241252265. DOI: 10.1177/20503121241252265.
Baasland I, Bjørge T, Engesæter B, Tropé A, Opdahl S. Cervical intraepithelial neoplasia grade 1 and long-term risk of progression and treatment. PLoS One. 2025;20(4):e0320739. DOI: 10.1371/journal.pone.0320739.
Doorbar J. The human Papillomavirus twilight zone – Latency, immune control and subclinical infection. Tumour Virus Res. 2023;16:200268. DOI: 10.1016/j.tvr.2023.200268.
Tekalegn Y, Sahiledengle B, Woldeyohannes D, Atlaw D, Degno S, Desta F, et al. High parity is associated with increased risk of cervical cancer: Systematic review and meta-analysis of case–control studies. Womens Health (Lond). 2022;18:17455065221075904. DOI: 10.1177/17455065221075904.
Ting J, Kruzikas DT, Smith JS. A global review of age-specific and overall prevalence of cervical lesions. Int J Gynecol Cancer. 2010;20(7):1244–9. DOI: 10.1111/IGC.0b013e3181f16c5f.
Tainio K, Athanasiou A, Tikkinen KAO, Aaltonen R, Cárdenas J, Hernándes null, et al. Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis. BMJ. 2018;360:k499. DOI: 10.1136/bmj.k499.
Sevilla MTS, Lacayo SL. Seguimiento y abordaje terapéutico que se les brinda a las mujeres con lesiones intraepiteliales del cuello uterino que son atendidas en el centro de salud Leonel Rugama, Estelí, Nicaragua, 2021. Revista Torreón Universitario. 2023;12(35):146–157. DOI: 10.5377/rtu.v12i35.17005.
Agüero DA, Castillo K, Blanco MG. Neoplasia intraepitelial cervical de alto grado en mujeres menores de 25 años y mayores de 45 años. Rev Obstet Ginecol Venez. 2012;72(2):89–102.
Hierrezuelo Rojas N, Carbó Cisnero Y. Factores de riesgo asociados a la neoplasia intraepitelial cervical en el Policlínico Ramón López Peña. Rev Cuba Obstet Ginecol. 2023;47(2):e783.
Follador K, Viçosa Pires L, Corbellini APZ, Zwir Poli JH, Jara Reis R, Suñé M da S, et al. High frequency of sexually transmitted infections in patients with precancerous cervical lesions in Brazil. Front Public Health. 2025;13:1480959. DOI:10.3389/fpubh.2025.1480959.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Alejandra Huayllasco Chafloque, Avry Stopp Wadsworth, Marcelo Menéndez Zúñiga, Rafael Herrera Delgado

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- The authors will retain their copyright and will guarantee to the journal right of first publication of their work, which will simultaneously be under a Creative Commons Attribution 4.0 License that allows third parties to share the work whenever attribuying their author and first publication in this journal.
- The Author is able to enter into separate, additional contractual arrangements for the nonexclusive distribution of the journal's published version of the Work (e.g., post it to an institutional repository or publish it in a book), as long as there is provided in the document an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post online a pre-publication manuscript (but not the Publisher’s final formatted PDF version of the Work) in institutional repositories or on their Websites prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (see The Effect of Open Access).





